| North West Counties Div One | ||||
| Date | Home | H | A | Away |
| 16/05/2001 | Leek CSOB | 1 | 1 | Flixton (R) |
| 15/05/2001 | Salford City | 3 | 0 | Ramsbottom United |
| 14/05/2001 | Leek CSOB | 1 | 2 | Maine Road |
| 12/05/2001 | Leek CSOB | 4 | 0 | Cheadle Town |
| 11/05/2001 | Kidsgrove Athletic | 1 | 1 | Clitheroe |
| 11/05/2001 | Ramsbottom United | 3 | 0 | Skelmersdale United |
| 09/05/2001 | Kidsgrove Athletic | 1 | 1 | Fleetwood Freeport |
| 08/05/2001 | Atherton Collieries | 0 | 0 | Nantwich Town |
| 08/05/2001 | Cheadle Town | 0 | 0 | Curzon Ashton (P) |
| 08/05/2001 | Maine Road | 3 | 0 | Flixton (R) |
| 08/05/2001 | Woodley Sports (P) | 1 | 5 | Ramsbottom United |
| 07/05/2001 | Clitheroe | 2 | 1 | Prescot Cables |
| 07/05/2001 | Fleetwood Freeport | 1 | 2 | St Helens Town |
| 07/05/2001 | Great Harwood Town | 2 | 2 | Mossley |
| 05/05/2001 | Abbey Hey | 4 | 0 | Glossop North End |
| 05/05/2001 | Atherton Collieries | 3 | 2 | Newcastle Town |
| 05/05/2001 | Clitheroe | 0 | 0 | St Helens Town |
| 05/05/2001 | Curzon Ashton (P) | 3 | 1 | Leek CSOB |
| 05/05/2001 | Fleetwood Freeport | 3 | 2 | Prescot Cables |
| 05/05/2001 | Flixton (R) | 0 | 4 | Rossendale United |
| 05/05/2001 | Mossley | 3 | 2 | Cheadle Town |
| 05/05/2001 | Skelmersdale United | 0 | 1 | Ramsbottom United |
| 04/05/2001 | Great Harwood Town | 0 | 2 | Nantwich Town |
| 03/05/2001 | Atherton Collieries | 1 | 0 | Skelmersdale United |
| 03/05/2001 | Curzon Ashton (P) | 1 | 0 | Woodley Sports (P) |
| 03/05/2001 | Ramsbottom United | 0 | 3 | Kidsgrove Athletic |
| 03/05/2001 | St Helens Town | 1 | 1 | Mossley |
| 01/05/2001 | Atherton Collieries | 0 | 2 | Ramsbottom United |
| 01/05/2001 | Fleetwood Freeport | 3 | 1 | Mossley |
| 01/05/2001 | Flixton (R) | 0 | 0 | Great Harwood Town |
| 01/05/2001 | Glossop North End | 0 | 3 | Clitheroe |
| 01/05/2001 | Rossendale United | 4 | 2 | Kidsgrove Athletic |
| 29/04/2001 | Great Harwood Town | 6 | 1 | Cheadle Town |
| 28/04/2001 | Abbey Hey | 3 | 1 | Newcastle Town |
| 28/04/2001 | Leek CSOB | 0 | 0 | St Helens Town |
| 28/04/2001 | Maine Road | 0 | 0 | Mossley |
| 28/04/2001 | Prescot Cables | 3 | 1 | Clitheroe |
| 28/04/2001 | Rossendale United | 8 | 0 | Glossop North End |
| 28/04/2001 | Salford City | 4 | 0 | Nantwich Town |
| 26/04/2001 | Great Harwood Town | 2 | 1 | Woodley Sports (P) |
| 26/04/2001 | Mossley | 0 | 3 | Rossendale United |
| 26/04/2001 | Prescot Cables | 2 | 1 | Atherton Collieries |
| 26/04/2001 | St Helens Town | 0 | 2 | Kidsgrove Athletic |
| 24/04/2001 | Clitheroe | 1 | 0 | Kidsgrove Athletic |
| 24/04/2001 | Flixton (R) | 1 | 4 | Fleetwood Freeport |
| 24/04/2001 | Ramsbottom United | 1 | 1 | Leek CSOB |
| 24/04/2001 | Salford City | 2 | 2 | Curzon Ashton (P) |
| 23/04/2001 | St Helens Town | 3 | 1 | Prescot Cables |
| 21/04/2001 | Clitheroe | 1 | 1 | Mossley |
| 21/04/2001 | Glossop North End | 1 | 2 | Salford City |
| 21/04/2001 | Kidsgrove Athletic | 1 | 0 | Curzon Ashton (P) |
| 21/04/2001 | Leek CSOB | 1 | 1 | Abbey Hey |
| 21/04/2001 | Nantwich Town | 2 | 0 | Great Harwood Town |
| 21/04/2001 | Newcastle Town | 4 | 0 | Ramsbottom United |
| 21/04/2001 | Rossendale United | 2 | 0 | Maine Road |
| 21/04/2001 | Skelmersdale United | 2 | 1 | Fleetwood Freeport |
| 21/04/2001 | Woodley Sports (P) | 3 | 4 | Prescot Cables |
| 19/04/2001 | Great Harwood Town | 1 | 0 | Atherton Collieries |
| 18/04/2001 | Glossop North End | 0 | 2 | Skelmersdale United |
| 18/04/2001 | Mossley | 1 | 2 | Abbey Hey |
| 18/04/2001 | Newcastle Town | 2 | 0 | Flixton (R) |
| 18/04/2001 | Ramsbottom United | 1 | 1 | Curzon Ashton (P) |
| 18/04/2001 | St Helens Town | 3 | 0 | Rossendale United |
| 16/04/2001 | Abbey Hey | 0 | 1 | Curzon Ashton (P) |
| 16/04/2001 | Atherton Collieries | 3 | 1 | Salford City |
| 16/04/2001 | Cheadle Town | 3 | 4 | Fleetwood Freeport |
| 16/04/2001 | Clitheroe | 6 | 1 | Great Harwood Town |
| 16/04/2001 | Glossop North End | 0 | 4 | Mossley |
| 16/04/2001 | Kidsgrove Athletic | 1 | 0 | Newcastle Town |
| 16/04/2001 | Rossendale United | 0 | 1 | Ramsbottom United |
| 16/04/2001 | Skelmersdale United | 1 | 0 | Leek CSOB |
| 14/04/2001 | Clitheroe | 4 | 0 | Glossop North End |
| 14/04/2001 | Curzon Ashton (P) | 0 | 0 | Salford City |
| 14/04/2001 | Fleetwood Freeport | 1 | 3 | Kidsgrove Athletic |
| 14/04/2001 | Flixton (R) | 3 | 1 | Maine Road |
| 14/04/2001 | Leek CSOB | 0 | 2 | Mossley |
| 14/04/2001 | Nantwich Town | 1 | 2 | Ramsbottom United |
| 14/04/2001 | Prescot Cables | 0 | 2 | Newcastle Town |
| 14/04/2001 | Rossendale United | 1 | 2 | St Helens Town |
| 14/04/2001 | Woodley Sports (P) | 1 | 1 | Atherton Collieries |
| 12/04/2001 | Great Harwood Town | 0 | 2 | Skelmersdale United |
| 12/04/2001 | Newcastle Town | 0 | 3 | Clitheroe |
| 12/04/2001 | Ramsbottom United | 2 | 0 | Prescot Cables |
| 11/04/2001 | St Helens Town | 5 | 2 | Curzon Ashton (P) |
| 10/04/2001 | Atherton Collieries | 3 | 2 | Prescot Cables |
| 10/04/2001 | Leek CSOB | 1 | 0 | Newcastle Town |
| 10/04/2001 | Mossley | 1 | 2 | Fleetwood Freeport |
| 10/04/2001 | Ramsbottom United | 6 | 1 | Maine Road |
| 10/04/2001 | Rossendale United | 3 | 0 | Abbey Hey |
| 10/04/2001 | Skelmersdale United | 1 | 0 | Flixton (R) |
| 09/04/2001 | Great Harwood Town | 0 | 1 | St Helens Town |
| 07/04/2001 | Kidsgrove Athletic | 3 | 4 | Abbey Hey |
| 07/04/2001 | Nantwich Town | 2 | 3 | Rossendale United |
| 03/04/2001 | Atherton Collieries | 0 | 2 | Clitheroe |
| 03/04/2001 | Curzon Ashton (P) | 3 | 2 | Newcastle Town |
| 03/04/2001 | Flixton (R) | 0 | 1 | Skelmersdale United |
| 03/04/2001 | Leek CSOB | 4 | 0 | Great Harwood Town |
| 03/04/2001 | Prescot Cables | 4 | 3 | Mossley |
| 03/04/2001 | Ramsbottom United | 1 | 0 | Abbey Hey |
| 03/04/2001 | Woodley Sports (P) | 2 | 1 | Fleetwood Freeport |
| 02/04/2001 | Maine Road | 1 | 3 | Kidsgrove Athletic |
| 31/03/2001 | Abbey Hey | 2 | 2 | Nantwich Town |
| 31/03/2001 | Cheadle Town | 2 | 0 | Flixton (R) |
| 31/03/2001 | Fleetwood Freeport | 0 | 1 | Rossendale United |
| 31/03/2001 | Great Harwood Town | 5 | 0 | Glossop North End |
| 31/03/2001 | Mossley | 1 | 1 | Clitheroe |
| 31/03/2001 | Salford City | 4 | 2 | Woodley Sports (P) |
| 30/03/2001 | St Helens Town | 0 | 0 | Leek CSOB |
| 29/03/2001 | Clitheroe | 1 | 0 | Fleetwood Freeport |
| 27/03/2001 | Atherton Collieries | 2 | 5 | Abbey Hey |
| 27/03/2001 | Clitheroe | 13 | 0 | Cheadle Town |
| 27/03/2001 | Curzon Ashton (P) | 1 | 2 | Fleetwood Freeport |
| 27/03/2001 | Ramsbottom United | 2 | 4 | St Helens Town |
| 27/03/2001 | Rossendale United | 2 | 1 | Newcastle Town |
| 27/03/2001 | Woodley Sports (P) | 1 | 0 | Mossley |
| 24/03/2001 | Abbey Hey | 7 | 0 | Cheadle Town |
| 24/03/2001 | Atherton Collieries | 0 | 1 | Mossley |
| 24/03/2001 | Curzon Ashton (P) | 3 | 1 | Nantwich Town |
| 24/03/2001 | Great Harwood Town | 2 | 3 | Kidsgrove Athletic |
| 24/03/2001 | Leek CSOB | 1 | 4 | Fleetwood Freeport |
| 24/03/2001 | Prescot Cables | 2 | 2 | Flixton (R) |
| 24/03/2001 | Ramsbottom United | 1 | 0 | Salford City |
| 24/03/2001 | Skelmersdale United | 2 | 1 | Rossendale United |
| 24/03/2001 | St Helens Town | 9 | 2 | Glossop North End |
| 24/03/2001 | Woodley Sports (P) | 3 | 0 | Maine Road |
| 22/03/2001 | Great Harwood Town | 0 | 1 | Prescot Cables |
| 21/03/2001 | St Helens Town | 2 | 0 | Fleetwood Freeport |
| 20/03/2001 | Flixton (R) | 0 | 2 | Kidsgrove Athletic |
| 20/03/2001 | Glossop North End | 2 | 3 | Abbey Hey |
| 20/03/2001 | Leek CSOB | 0 | 1 | Atherton Collieries |
| 20/03/2001 | Mossley | 0 | 1 | Nantwich Town |
| 20/03/2001 | Newcastle Town | 0 | 1 | Prescot Cables |
| 20/03/2001 | Ramsbottom United | 1 | 1 | Great Harwood Town |
| 20/03/2001 | Rossendale United | 4 | 1 | Curzon Ashton (P) |
| 17/03/2001 | Atherton Collieries | 2 | 0 | Great Harwood Town |
| 17/03/2001 | Cheadle Town | 1 | 3 | St Helens Town |
| 17/03/2001 | Fleetwood Freeport | 2 | 0 | Newcastle Town |
| 17/03/2001 | Flixton (R) | 1 | 5 | Ramsbottom United |
| 17/03/2001 | Glossop North End | 1 | 2 | Kidsgrove Athletic |
| 17/03/2001 | Maine Road | 2 | 4 | Prescot Cables |
| 17/03/2001 | Nantwich Town | 3 | 2 | Skelmersdale United |
| 17/03/2001 | Rossendale United | 1 | 1 | Leek CSOB |
| 17/03/2001 | Woodley Sports (P) | 0 | 0 | Salford City |
| 15/03/2001 | Nantwich Town | 0 | 0 | Newcastle Town |
| 15/03/2001 | Rossendale United | 6 | 1 | Flixton (R) |
| 14/03/2001 | Prescot Cables | 0 | 2 | Great Harwood Town |
| 14/03/2001 | Skelmersdale United | 2 | 3 | Kidsgrove Athletic |
| 13/03/2001 | Abbey Hey | 1 | 2 | Rossendale United |
| 13/03/2001 | Atherton Collieries | 1 | 0 | St Helens Town |
| 13/03/2001 | Cheadle Town | 2 | 2 | Woodley Sports (P) |
| 13/03/2001 | Curzon Ashton (P) | 2 | 3 | Maine Road |
| 13/03/2001 | Ramsbottom United | 3 | 2 | Fleetwood Freeport |
| 13/03/2001 | Salford City | 3 | 0 | Glossop North End |
| 10/03/2001 | Leek CSOB | 1 | 3 | Clitheroe |
| 10/03/2001 | Rossendale United | 9 | 1 | Cheadle Town |
| 10/03/2001 | Salford City | 2 | 0 | Flixton (R) |
| 10/03/2001 | Skelmersdale United | 1 | 2 | Maine Road |
| 10/03/2001 | St Helens Town | 1 | 2 | Ramsbottom United |
| 09/03/2001 | Kidsgrove Athletic | 3 | 3 | Great Harwood Town |
| 08/03/2001 | Cheadle Town | 1 | 4 | Clitheroe |
| 06/03/2001 | Abbey Hey | 0 | 0 | Clitheroe |
| 06/03/2001 | Atherton Collieries | 1 | 2 | Flixton (R) |
| 06/03/2001 | Curzon Ashton (P) | 2 | 2 | Cheadle Town |
| 06/03/2001 | Mossley | 0 | 2 | Kidsgrove Athletic |
| 06/03/2001 | Prescot Cables | 0 | 1 | Skelmersdale United |
| 06/03/2001 | Ramsbottom United | 3 | 0 | Glossop North End |
| 06/03/2001 | Rossendale United | 2 | 1 | Fleetwood Freeport |
| 06/03/2001 | Woodley Sports (P) | 2 | 0 | St Helens Town |
| 03/03/2001 | Curzon Ashton (P) | 0 | 2 | Prescot Cables |
| 03/03/2001 | Flixton (R) | 1 | 6 | Mossley |
| 03/03/2001 | Leek CSOB | 2 | 5 | Ramsbottom United |
| 03/03/2001 | Newcastle Town | 1 | 0 | St Helens Town |
| 02/03/2001 | Maine Road | 3 | 4 | Fleetwood Freeport |
| 01/03/2001 | Skelmersdale United | 4 | 3 | Prescot Cables |
| 27/02/2001 | Glossop North End | 1 | 5 | Fleetwood Freeport |
| 24/02/2001 | Abbey Hey | 2 | 2 | Leek CSOB |
| 24/02/2001 | Fleetwood Freeport | 1 | 0 | Nantwich Town |
| 24/02/2001 | Glossop North End | 0 | 0 | Curzon Ashton (P) |
| 24/02/2001 | Kidsgrove Athletic | 3 | 1 | Flixton (R) |
| 24/02/2001 | Mossley | 2 | 1 | Maine Road |
| 24/02/2001 | Newcastle Town | 0 | 0 | Great Harwood Town |
| 24/02/2001 | Prescot Cables | 6 | 1 | Cheadle Town |
| 24/02/2001 | Salford City | 1 | 4 | Clitheroe |
| 24/02/2001 | Skelmersdale United | 0 | 0 | Atherton Collieries |
| 24/02/2001 | Woodley Sports (P) | 0 | 2 | Rossendale United |
| 22/02/2001 | Nantwich Town | 0 | 1 | Prescot Cables |
| 21/02/2001 | St Helens Town | 2 | 1 | Newcastle Town |
| 20/02/2001 | Abbey Hey | 2 | 3 | Woodley Sports (P) |
| 20/02/2001 | Atherton Collieries | 0 | 6 | Fleetwood Freeport |
| 20/02/2001 | Flixton (R) | 2 | 4 | Curzon Ashton (P) |
| 20/02/2001 | Kidsgrove Athletic | 5 | 0 | Leek CSOB |
| 20/02/2001 | Maine Road | 1 | 8 | Skelmersdale United |
| 20/02/2001 | Ramsbottom United | 1 | 2 | Cheadle Town |
| 20/02/2001 | Rossendale United | 7 | 1 | Great Harwood Town |
| 17/02/2001 | Great Harwood Town | 1 | 3 | Curzon Ashton (P) |
| 17/02/2001 | Leek CSOB | 0 | 4 | Salford City |
| 17/02/2001 | Maine Road | 5 | 2 | Abbey Hey |
| 17/02/2001 | Nantwich Town | 1 | 0 | Cheadle Town |
| 17/02/2001 | Prescot Cables | 5 | 0 | Glossop North End |
| 17/02/2001 | Ramsbottom United | 2 | 1 | Flixton (R) |
| 17/02/2001 | Rossendale United | 5 | 1 | Atherton Collieries |
| 17/02/2001 | Woodley Sports (P) | 0 | 0 | Skelmersdale United |
| 13/02/2001 | Abbey Hey | 1 | 1 | Great Harwood Town |
| 13/02/2001 | Atherton Collieries | 0 | 4 | Woodley Sports (P) |
| 13/02/2001 | Cheadle Town | 3 | 0 | Glossop North End |
| 13/02/2001 | Clitheroe | 3 | 0 | Maine Road |
| 13/02/2001 | Nantwich Town | 1 | 5 | Mossley |
| 13/02/2001 | Rossendale United | 1 | 1 | Prescot Cables |
| 10/02/2001 | Abbey Hey | 1 | 0 | Atherton Collieries |
| 10/02/2001 | Flixton (R) | 1 | 2 | Salford City |
| 10/02/2001 | Glossop North End | 0 | 1 | Ramsbottom United |
| 10/02/2001 | Kidsgrove Athletic | 2 | 1 | Nantwich Town |
| 10/02/2001 | Leek CSOB | 2 | 4 | Woodley Sports (P) |
| 10/02/2001 | Maine Road | 3 | 2 | Curzon Ashton (P) |
| 10/02/2001 | Skelmersdale United | 1 | 1 | Newcastle Town |
| 06/02/2001 | Cheadle Town | 0 | 5 | Kidsgrove Athletic |
| 06/02/2001 | Prescot Cables | 4 | 1 | Abbey Hey |
| 06/02/2001 | Woodley Sports (P) | 2 | 2 | Nantwich Town |
| 03/02/2001 | Curzon Ashton (P) | 4 | 1 | Glossop North End |
| 03/02/2001 | Great Harwood Town | 0 | 1 | Leek CSOB |
| 03/02/2001 | Nantwich Town | 0 | 5 | Clitheroe |
| 03/02/2001 | Newcastle Town | 6 | 0 | Maine Road |
| 03/02/2001 | Rossendale United | 2 | 0 | Mossley |
| 03/02/2001 | Salford City | 5 | 0 | Abbey Hey |
| 03/02/2001 | Skelmersdale United | 2 | 3 | St Helens Town |
| 31/01/2001 | St Helens Town | 1 | 1 | Nantwich Town |
| 30/01/2001 | Cheadle Town | 2 | 4 | Newcastle Town |
| 30/01/2001 | Fleetwood Freeport | 4 | 3 | Maine Road |
| 30/01/2001 | Flixton (R) | 0 | 0 | Woodley Sports (P) |
| 29/01/2001 | Great Harwood Town | 2 | 3 | Rossendale United |
| 27/01/2001 | Abbey Hey | 0 | 4 | Skelmersdale United |
| 27/01/2001 | Cheadle Town | 1 | 1 | Salford City |
| 27/01/2001 | Clitheroe | 0 | 1 | Newcastle Town |
| 27/01/2001 | Flixton (R) | 3 | 2 | Nantwich Town |
| 27/01/2001 | Glossop North End | 2 | 0 | Great Harwood Town |
| 27/01/2001 | Kidsgrove Athletic | 4 | 0 | Atherton Collieries |
| 27/01/2001 | Mossley | 1 | 2 | Ramsbottom United |
| 27/01/2001 | Prescot Cables | 0 | 2 | Rossendale United |
| 26/01/2001 | Maine Road | 2 | 0 | Woodley Sports (P) |
| 23/01/2001 | Newcastle Town | 6 | 0 | Atherton Collieries |
| 23/01/2001 | Salford City | 7 | 0 | Cheadle Town |
| 20/01/2001 | Fleetwood Freeport | 2 | 0 | Cheadle Town |
| 20/01/2001 | Newcastle Town | 4 | 1 | Abbey Hey |
| 13/01/2001 | Abbey Hey | 0 | 1 | Kidsgrove Athletic |
| 13/01/2001 | Atherton Collieries | 0 | 4 | Curzon Ashton (P) |
| 13/01/2001 | Cheadle Town | 0 | 0 | Leek CSOB |
| 13/01/2001 | Clitheroe | 1 | 2 | Rossendale United |
| 13/01/2001 | Fleetwood Freeport | 3 | 0 | Glossop North End |
| 13/01/2001 | Mossley | 2 | 0 | Flixton (R) |
| 13/01/2001 | Newcastle Town | 2 | 2 | Skelmersdale United |
| 13/01/2001 | Prescot Cables | 1 | 1 | Salford City |
| 13/01/2001 | Ramsbottom United | 2 | 0 | Nantwich Town |
| 13/01/2001 | St Helens Town | 2 | 0 | Maine Road |
| 13/01/2001 | Woodley Sports (P) | 6 | 0 | Great Harwood Town |
| 06/01/2001 | Atherton Collieries | 1 | 1 | Glossop North End |
| 06/01/2001 | Maine Road | 0 | 3 | Salford City |
| 06/01/2001 | Nantwich Town | 1 | 3 | Leek CSOB |
| 06/01/2001 | Newcastle Town | 3 | 0 | Woodley Sports (P) |
| 06/01/2001 | Prescot Cables | 0 | 2 | St Helens Town |
| 03/01/2001 | St Helens Town | 10 | 2 | Abbey Hey |
| 02/01/2001 | Curzon Ashton (P) | 3 | 0 | Great Harwood Town |
| 02/01/2001 | Nantwich Town | 1 | 2 | Salford City |
| 02/01/2001 | Woodley Sports (P) | 3 | 1 | Leek CSOB |
| 26/12/2000 | Cheadle Town | 1 | 1 | Abbey Hey |
| 26/12/2000 | Fleetwood Freeport | 2 | 1 | Atherton Collieries |
| 26/12/2000 | Great Harwood Town | 1 | 2 | Clitheroe |
| 26/12/2000 | Leek CSOB | 1 | 1 | Nantwich Town |
| 26/12/2000 | Mossley | 2 | 2 | Glossop North End |
| 26/12/2000 | Newcastle Town | 1 | 1 | Kidsgrove Athletic |
| 26/12/2000 | Ramsbottom United | 3 | 0 | Rossendale United |
| 26/12/2000 | Salford City | 3 | 0 | Maine Road |
| 26/12/2000 | Skelmersdale United | 3 | 0 | Woodley Sports (P) |
| 23/12/2000 | Abbey Hey | 1 | 5 | Fleetwood Freeport |
| 23/12/2000 | Cheadle Town | 2 | 1 | Atherton Collieries |
| 23/12/2000 | Clitheroe | 2 | 4 | Flixton (R) |
| 23/12/2000 | Curzon Ashton (P) | 0 | 0 | Rossendale United |
| 23/12/2000 | Great Harwood Town | 1 | 1 | Salford City |
| 23/12/2000 | Kidsgrove Athletic | 1 | 1 | Ramsbottom United |
| 23/12/2000 | Maine Road | 4 | 1 | Leek CSOB |
| 23/12/2000 | Mossley | 2 | 1 | Skelmersdale United |
| 23/12/2000 | Newcastle Town | 2 | 1 | Glossop North End |
| 20/12/2000 | Curzon Ashton (P) | 0 | 1 | Clitheroe |
| 20/12/2000 | St Helens Town | 5 | 0 | Flixton (R) |
| 18/12/2000 | Great Harwood Town | 0 | 3 | Fleetwood Freeport |
| 16/12/2000 | Fleetwood Freeport | 1 | 0 | Leek CSOB |
| 16/12/2000 | Glossop North End | 1 | 2 | Rossendale United |
| 16/12/2000 | Kidsgrove Athletic | 0 | 1 | Woodley Sports (P) |
| 16/12/2000 | Maine Road | 0 | 1 | Newcastle Town |
| 16/12/2000 | Skelmersdale United | 1 | 2 | Curzon Ashton (P) |
| 16/12/2000 | St Helens Town | 1 | 2 | Clitheroe |
| 12/12/2000 | Mossley | 1 | 2 | St Helens Town |
| 12/12/2000 | Nantwich Town | 2 | 1 | Abbey Hey |
| 12/12/2000 | Newcastle Town | 2 | 0 | Leek CSOB |
| 09/12/2000 | Abbey Hey | 4 | 0 | Flixton (R) |
| 09/12/2000 | Cheadle Town | 0 | 2 | Maine Road |
| 09/12/2000 | Curzon Ashton (P) | 5 | 2 | Atherton Collieries |
| 09/12/2000 | Salford City | 0 | 2 | Kidsgrove Athletic |
| 05/12/2000 | Maine Road | 0 | 3 | Ramsbottom United |
| 02/12/2000 | Fleetwood Freeport | 4 | 2 | Abbey Hey |
| 02/12/2000 | Glossop North End | 1 | 2 | Prescot Cables |
| 02/12/2000 | Kidsgrove Athletic | 2 | 2 | Rossendale United |
| 02/12/2000 | Maine Road | 3 | 3 | Clitheroe |
| 02/12/2000 | Nantwich Town | 3 | 1 | Curzon Ashton (P) |
| 02/12/2000 | Newcastle Town | 2 | 0 | Cheadle Town |
| 02/12/2000 | Ramsbottom United | 4 | 1 | Mossley |
| 02/12/2000 | Salford City | 2 | 1 | Leek CSOB |
| 02/12/2000 | Skelmersdale United | 0 | 2 | Great Harwood Town |
| 02/12/2000 | St Helens Town | 2 | 0 | Atherton Collieries |
| 02/12/2000 | Woodley Sports (P) | 5 | 1 | Flixton (R) |
| 28/11/2000 | Fleetwood Freeport | 1 | 1 | Woodley Sports (P) |
| 25/11/2000 | Abbey Hey | 0 | 4 | St Helens Town |
| 21/11/2000 | Fleetwood Freeport | 4 | 0 | Clitheroe |
| 21/11/2000 | Salford City | 1 | 0 | Mossley |
| 18/11/2000 | Clitheroe | 3 | 1 | Skelmersdale United |
| 18/11/2000 | Flixton (R) | 3 | 0 | Atherton Collieries |
| 18/11/2000 | Glossop North End | 3 | 1 | Leek CSOB |
| 18/11/2000 | Rossendale United | 3 | 1 | Woodley Sports (P) |
| 11/11/2000 | Curzon Ashton (P) | 1 | 0 | Flixton (R) |
| 11/11/2000 | Salford City | 4 | 0 | Great Harwood Town |
| 11/11/2000 | Woodley Sports (P) | 1 | 4 | Kidsgrove Athletic |
| 04/11/2000 | Clitheroe | 2 | 1 | Ramsbottom United |
| 04/11/2000 | Fleetwood Freeport | 1 | 0 | Salford City |
| 04/11/2000 | Kidsgrove Athletic | 1 | 4 | Mossley |
| 04/11/2000 | Prescot Cables | 7 | 1 | Leek CSOB |
| 04/11/2000 | Rossendale United | 7 | 1 | Skelmersdale United |
| 02/11/2000 | Maine Road | 3 | 3 | Atherton Collieries |
| 31/10/2000 | Newcastle Town | 2 | 0 | Nantwich Town |
| 31/10/2000 | Salford City | 2 | 0 | Atherton Collieries |
| 28/10/2000 | Flixton (R) | 1 | 1 | Cheadle Town |
| 28/10/2000 | Nantwich Town | 0 | 1 | Fleetwood Freeport |
| 28/10/2000 | Newcastle Town | 2 | 3 | Curzon Ashton (P) |
| 27/10/2000 | Maine Road | 3 | 2 | Great Harwood Town |
| 25/10/2000 | St Helens Town | 1 | 1 | Salford City |
| 24/10/2000 | Cheadle Town | 0 | 4 | Prescot Cables |
| 24/10/2000 | Glossop North End | 2 | 3 | Nantwich Town |
| 24/10/2000 | Kidsgrove Athletic | 2 | 1 | Maine Road |
| 24/10/2000 | Skelmersdale United | 3 | 2 | Mossley |
| 24/10/2000 | Woodley Sports (P) | 3 | 1 | Clitheroe |
| 21/10/2000 | Maine Road | 2 | 3 | Glossop North End |
| 21/10/2000 | Mossley | 1 | 3 | Newcastle Town |
| 21/10/2000 | Salford City | 4 | 0 | Skelmersdale United |
| 14/10/2000 | Atherton Collieries | 0 | 3 | Rossendale United |
| 14/10/2000 | Clitheroe | 3 | 5 | Abbey Hey |
| 14/10/2000 | Flixton (R) | 1 | 1 | Leek CSOB |
| 14/10/2000 | Kidsgrove Athletic | 0 | 2 | Salford City |
| 14/10/2000 | Maine Road | 3 | 2 | Cheadle Town |
| 14/10/2000 | Newcastle Town | 1 | 0 | Fleetwood Freeport |
| 14/10/2000 | Prescot Cables | 6 | 0 | Curzon Ashton (P) |
| 14/10/2000 | Woodley Sports (P) | 1 | 2 | Glossop North End |
| 13/10/2000 | St Helens Town | 4 | 0 | Great Harwood Town |
| 10/10/2000 | Kidsgrove Athletic | 0 | 3 | Prescot Cables |
| 07/10/2000 | Cheadle Town | 1 | 3 | Skelmersdale United |
| 07/10/2000 | Curzon Ashton (P) | 0 | 3 | Ramsbottom United |
| 07/10/2000 | Fleetwood Freeport | 2 | 2 | Flixton (R) |
| 07/10/2000 | Mossley | 1 | 1 | Woodley Sports (P) |
| 06/10/2000 | Salford City | 1 | 2 | Newcastle Town |
| 05/10/2000 | Nantwich Town | 3 | 1 | Maine Road |
| 04/10/2000 | St Helens Town | 1 | 2 | Woodley Sports (P) |
| 03/10/2000 | Cheadle Town | 3 | 2 | Nantwich Town |
| 03/10/2000 | Clitheroe | 2 | 2 | Curzon Ashton (P) |
| 03/10/2000 | Glossop North End | 2 | 2 | Flixton (R) |
| 03/10/2000 | Mossley | 3 | 0 | Leek CSOB |
| 03/10/2000 | Prescot Cables | 1 | 1 | Kidsgrove Athletic |
| 03/10/2000 | Rossendale United | 2 | 2 | Salford City |
| 03/10/2000 | Skelmersdale United | 2 | 0 | Abbey Hey |
| 02/10/2000 | Great Harwood Town | 2 | 3 | Ramsbottom United |
| 30/09/2000 | Abbey Hey | 1 | 3 | Prescot Cables |
| 30/09/2000 | Curzon Ashton (P) | 1 | 3 | St Helens Town |
| 30/09/2000 | Glossop North End | 1 | 0 | Cheadle Town |
| 30/09/2000 | Great Harwood Town | 1 | 6 | Maine Road |
| 30/09/2000 | Kidsgrove Athletic | 5 | 2 | Skelmersdale United |
| 30/09/2000 | Leek CSOB | 0 | 4 | Rossendale United |
| 30/09/2000 | Nantwich Town | 1 | 1 | Atherton Collieries |
| 30/09/2000 | Ramsbottom United | 3 | 0 | Woodley Sports (P) |
| 27/09/2000 | St Helens Town | 3 | 1 | Cheadle Town |
| 26/09/2000 | Atherton Collieries | 3 | 2 | Maine Road |
| 26/09/2000 | Flixton (R) | 1 | 2 | Clitheroe |
| 26/09/2000 | Leek CSOB | 1 | 1 | Kidsgrove Athletic |
| 26/09/2000 | Mossley | 3 | 0 | Curzon Ashton (P) |
| 26/09/2000 | Newcastle Town | 1 | 2 | Salford City |
| 26/09/2000 | Prescot Cables | 1 | 0 | Ramsbottom United |
| 26/09/2000 | Skelmersdale United | 1 | 1 | Nantwich Town |
| 23/09/2000 | Clitheroe | 3 | 0 | Nantwich Town |
| 23/09/2000 | Newcastle Town | 0 | 1 | Mossley |
| 23/09/2000 | Skelmersdale United | 3 | 1 | Glossop North End |
| 20/09/2000 | Curzon Ashton (P) | 4 | 0 | Skelmersdale United |
| 19/09/2000 | Clitheroe | 4 | 2 | Atherton Collieries |
| 19/09/2000 | Glossop North End | 0 | 3 | St Helens Town |
| 19/09/2000 | Maine Road | 0 | 1 | Rossendale United |
| 19/09/2000 | Mossley | 2 | 0 | Prescot Cables |
| 19/09/2000 | Nantwich Town | 1 | 2 | Kidsgrove Athletic |
| 19/09/2000 | Ramsbottom United | 3 | 0 | Newcastle Town |
| 19/09/2000 | Salford City | 1 | 0 | Fleetwood Freeport |
| 18/09/2000 | Great Harwood Town | 2 | 1 | Abbey Hey |
| 16/09/2000 | Abbey Hey | 5 | 1 | Maine Road |
| 16/09/2000 | Cheadle Town | 1 | 6 | Rossendale United |
| 16/09/2000 | Nantwich Town | 0 | 1 | Glossop North End |
| 16/09/2000 | Prescot Cables | 2 | 1 | Woodley Sports (P) |
| 13/09/2000 | Woodley Sports (P) | 5 | 2 | Cheadle Town |
| 12/09/2000 | Abbey Hey | 1 | 3 | Salford City |
| 12/09/2000 | Fleetwood Freeport | 4 | 1 | Ramsbottom United |
| 12/09/2000 | Flixton (R) | 1 | 5 | Glossop North End |
| 12/09/2000 | Prescot Cables | 5 | 0 | Nantwich Town |
| 12/09/2000 | Skelmersdale United | 2 | 2 | Clitheroe |
| 09/09/2000 | Atherton Collieries | 3 | 2 | Cheadle Town |
| 09/09/2000 | Clitheroe | 5 | 1 | Woodley Sports (P) |
| 09/09/2000 | Curzon Ashton (P) | 0 | 4 | Abbey Hey |
| 09/09/2000 | Flixton (R) | 2 | 2 | Newcastle Town |
| 09/09/2000 | Kidsgrove Athletic | 0 | 1 | Glossop North End |
| 09/09/2000 | Leek CSOB | 1 | 1 | Skelmersdale United |
| 09/09/2000 | Mossley | 3 | 0 | Great Harwood Town |
| 09/09/2000 | Salford City | 1 | 1 | St Helens Town |
| 08/09/2000 | Maine Road | 4 | 2 | Nantwich Town |
| 05/09/2000 | Cheadle Town | 0 | 1 | Mossley |
| 05/09/2000 | Curzon Ashton (P) | 0 | 2 | Kidsgrove Athletic |
| 05/09/2000 | Glossop North End | 0 | 3 | Atherton Collieries |
| 05/09/2000 | Leek CSOB | 0 | 5 | Prescot Cables |
| 05/09/2000 | Nantwich Town | 0 | 4 | St Helens Town |
| 05/09/2000 | Salford City | 3 | 1 | Rossendale United |
| 05/09/2000 | Woodley Sports (P) | 1 | 1 | Newcastle Town |
| 04/09/2000 | Great Harwood Town | 2 | 2 | Flixton (R) |
| 02/09/2000 | Kidsgrove Athletic | 0 | 0 | St Helens Town |
| 29/08/2000 | Ramsbottom United | 0 | 1 | Clitheroe |
| 29/08/2000 | Skelmersdale United | 2 | 0 | Cheadle Town |
| 28/08/2000 | Abbey Hey | 1 | 2 | Mossley |
| 28/08/2000 | Atherton Collieries | 3 | 1 | Leek CSOB |
| 28/08/2000 | Fleetwood Freeport | 1 | 1 | Curzon Ashton (P) |
| 28/08/2000 | Flixton (R) | 4 | 4 | St Helens Town |
| 28/08/2000 | Glossop North End | 1 | 2 | Newcastle Town |
| 28/08/2000 | Nantwich Town | 1 | 2 | Woodley Sports (P) |
| 28/08/2000 | Salford City | 0 | 1 | Prescot Cables |
| 26/08/2000 | Cheadle Town | 0 | 3 | Ramsbottom United |
| 26/08/2000 | Clitheroe | 1 | 0 | Salford City |
| 26/08/2000 | Fleetwood Freeport | 2 | 1 | Skelmersdale United |
| 26/08/2000 | Flixton (R) | 2 | 2 | Prescot Cables |
| 26/08/2000 | Glossop North End | 1 | 4 | Maine Road |
| 26/08/2000 | Great Harwood Town | 0 | 2 | Newcastle Town |
| 26/08/2000 | Leek CSOB | 0 | 1 | Curzon Ashton (P) |
| 26/08/2000 | Mossley | 2 | 0 | Atherton Collieries |
| 26/08/2000 | Rossendale United | 1 | 2 | Nantwich Town |
| 26/08/2000 | Woodley Sports (P) | 0 | 1 | Abbey Hey |
| 23/08/2000 | St Helens Town | 2 | 1 | Skelmersdale United |
| 23/08/2000 | Woodley Sports (P) | 0 | 3 | Curzon Ashton (P) |
| 22/08/2000 | Fleetwood Freeport | 1 | 0 | Great Harwood Town |
| 22/08/2000 | Flixton (R) | 1 | 2 | Abbey Hey |
| 22/08/2000 | Kidsgrove Athletic | 1 | 1 | Cheadle Town |
| 22/08/2000 | Leek CSOB | 1 | 2 | Glossop North End |
| 22/08/2000 | Mossley | 5 | 4 | Salford City |
| 22/08/2000 | Prescot Cables | 0 | 2 | Maine Road |
| 22/08/2000 | Ramsbottom United | 1 | 0 | Atherton Collieries |
| 22/08/2000 | Rossendale United | 1 | 3 | Clitheroe |
| 19/08/2000 | Abbey Hey | 2 | 1 | Ramsbottom United |
| 19/08/2000 | Atherton Collieries | 0 | 1 | Kidsgrove Athletic |
| 19/08/2000 | Cheadle Town | 1 | 1 | Great Harwood Town |
| 19/08/2000 | Clitheroe | 4 | 1 | Leek CSOB |
| 19/08/2000 | Curzon Ashton (P) | 1 | 0 | Mossley |
| 19/08/2000 | Glossop North End | 0 | 3 | Woodley Sports (P) |
| 19/08/2000 | Maine Road | 1 | 2 | St Helens Town |
| 19/08/2000 | Nantwich Town | 0 | 0 | Flixton (R) |
| 19/08/2000 | Newcastle Town | 0 | 1 | Rossendale United |
| 19/08/2000 | Prescot Cables | 2 | 1 | Fleetwood Freeport |
| 19/08/2000 | Skelmersdale United | 3 | 3 | Salford City |